Bmscs Reduce Rat Granulosa Cell Apoptosis Induced by Cisplatin and Perimenopause

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  • 作者：Guo, J. Q., Gao, X., Lin, Z. J., Wu, W. Z., Huang, L. H., Dong, H. Y., Chen, J., Lu, J., Fu, Y. F., Wang, J., Ma, Y. J., Chen, X. W., Wu, Z. X., He, F. Q., Yang, S. L., Liao, L. M., Zheng, F. & Tan, J. M.
  • 期刊：BMC cell biology 14, 18 (2013)
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BACKGROUND: The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats. RESULTS: Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced upon co-culture with BMSCs to 4.84%. Cisplatin treatment increased p21 and bax and decreased c-myc mRNA expression, which was reversed upon co-culture with BMSCs. As compared to young rats, increased apoptosis was observed in the perimenopausal rats (P?文章引用产品